منابع مشابه
Stem Cells So far! Stem Cell Therapy Facts and Principles
Stem cells are cells with the ability to divide for indefinite periods and to give rise to specialized cells. Stem cell therapy has now been emerged as an extraordinary promise to treat a wide range of diseases and conditions. However, except blood stem cell transfer by bone marrow transplant which has been used as an standard practice for more than 50 years, nearly all of therapeutic potenti...
متن کاملGastrointestinal stem cells. II. Intestinal stem cells.
Current views of the identity, distribution, and regulation of small intestinal epithelial stem cells and their immediate progeny are discussed. Recent works implicating Wnt signaling in stem and progenitor proliferation, the involvement of Notch signaling in epithelial lineage specification, and the role of hedgehog and bone morphogenetic protein families in crypt formation are integrated. We ...
متن کاملElucidation of Cell Fate Transitions in Lung Cancer Stem Cells
Our goal in this proposed project in the Aerodigestive Programme is to explore cell-fate transitions in a CSC model and to use the data we generate to create predictive models that capture key interactions in the system and which can help distinguish NSC and CSC by using advanced methods including newly developed 3D organoid assays from human and mouse lungs, genetic gene manipulations with CRI...
متن کاملCell Fate and Differentiation of Bone Marrow Mesenchymal Stem Cells
Osteoblasts and bone marrow adipocytes originate from bone marrow mesenchymal stem cells (BMMSCs) and there appears to be a reciprocal relationship between adipogenesis and osteoblastogenesis. Alterations in the balance between adipogenesis and osteoblastogenesis in BMMSCs wherein adipogenesis is increased relative to osteoblastogenesis are associated with decreased bone quality and quantity. S...
متن کاملMicroprinted feeder cells guide embryonic stem cell fate.
We introduce a non-contact approach to microprint multiple types of feeder cells in a microarray format using immiscible aqueous solutions of two biopolymers. Droplets of cell suspension in the denser aqueous phase are printed on a substrate residing within a bath of the immersion aqueous phase. Due to their affinity to the denser phase, cells remain localized within the drops and adhere to reg...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Gastroenterology & Hepatology
سال: 2018
ISSN: 1759-5045,1759-5053
DOI: 10.1038/s41575-018-0096-4